Source Article link: https://medicalxpress.com/news/2022-02-team-cells-tools-huntington-als.html So.... When neuron become strassed, like in inflammation or infection, they produce proteins in respnse. In order to produce protein they need to read the right part of their DNA, and then transcribe that into messengerRNA. Then mRNA is used to create chain of amino-acids (translation) which then is folded into … Continue reading The Mystery of Familial and Sporadic Neurodegenerative Diseases Expalined. Is A Cure Found, Soon? $AVXL Blarcamesine
More Research Papers Pointing to SIGMAR1 Agonists As Possible Drugs For Alzheimer's and Parkinson's Please, read this article on the cell stress and its effect of misfolded protein in cells. Link: https://medicalxpress.com/news/2022-05-stressed-cells-clues-build-up-toxic.html In some sense this article could not be possible without the imaging technology which allows to visualize the transition from misfolded proteins to … Continue reading That Little Cell Stress That Does It….Or Right Chaperone Protein For Right Misfolded Protein In Alzheimer’s and Parkinson’s. $AVXL Blarcamesine.
Disclaimers .. Disclaimers... But It Has Been Said by Chief Medical Officer That..... I place a standard disclaimer so that I won't be sued if somebody loses any money following this blog. Just read for entertainment (isn't it pretty funny? 😉 ) but don't invest. LOL. Nevertheless, the Chief Medical Officer on March 14, 2022 … Continue reading Institutional Investors Bet Equally on $AVXL and $SAVA Prospects. Will Results of $AVXL Alzheimer’s Phase 2b/3 Alter This? $SAVA $AVXL
Study Looks At Mitochondria In Genetic Model Of Parkinson's The fabled energy machines of the human cell, Mitochondria, have been for long regarded as ancient organisms which evolved from symbiotic organism into indispensable organels of human cells (animal and plant cells). The vestige of this process is the fact that Mitochondria posses their own DNA, … Continue reading Blarcamesine Has Been All About Mitochondrial Health For Years. Now, Parkinson’s Study Looks At Mitochondrial Health. $AVXL
One Picture Worth Few Drugs.... Section of AD/PD Conference 2022 Poster presented by Anavex Life Sciences. The full poster can be downloaded at https://79bcf7a1-8b8e-483b-b7cf-f5c5192a6d63.usrfiles.com/ugd/79bcf7_ff6b864593fb4418ab306474dd535d35.pdf Before I delve into the pretty picture here I shall reference the UPDRS content as it is undoubtfully of great value in understanding the implications of this section of the poster. … Continue reading Looking Under The Hood of PDD Phase 2 Blarcamsine Results. $AVXL $ANVS
Returning To My Old Friend... I have found outside of any paywall a very usefull paper as it looked at about six years of following probable Alzheimer's patients population of some 300 to 400 subjects. I derived many of my conclusions on Blarcamesine performance from this paper's content. The many assertion this paper was making … Continue reading Does 93% Of Patients Going Into Open Label Extension Bode Well For Blarcamesine Or Not?
The Way of the Engineer.... In engineering if you can not find an analytical solution you asymptotically move toward solution through iterative calculations making your error smaller with every cycle and making assumptions. I once talked with Phd (mathematics) guy and he derisively asserted that if in engineering you are within 20% of solution you … Continue reading Comparing Trofinetide and Anavex2-73. This Installment We Try to Estimate RSBQ Score of AVATAR RS-002 From Hearsay and Formulas for Cohen’s d for RSBQ-ACU. All for Rett Syndrome Winning Drug. $AVXL $ACAD
I was asked.... ...to comapre directly the performance of $ACAD Trofinetide to Anavex2-73 in RS-002 Avatar. It took me some time to analyse how to do it, and I found the only possible way at this time to use the data supplied by $ACAD to apply the AUC treatment to its results. The available data … Continue reading RSBQ-AUC, a More Sensitive Measure of Rett Syndrome Data. Now Applied to $ACAD Trofinetide. Ready Comparison to $AVXL Anavex2-73.
I was informed that what market fear is that ..... On Stocktwits I got following message. Let us examine this claim.... We have to asks ourselves what is the p-vlaue and how is it calculated? For the null hypothesis to be true is that large enough number of the values of the sample (Dose cohort) … Continue reading P-values Fears And Jesus Visits The Placebo Arm of AVATAR Rett Syndrome Anavex2-73 $AVXL
Better Does Not Mean More Familiar The first issue I want to discuss is the CGI-I anchoring of RSBQ-AUC, or rather the familiar RSBQ that is here the raw data. If the CGI-I score improves (drops) by one point out of the 3 possible to describe the improvement then the RSBQ scores are accepted for … Continue reading FDA Made $AVXL Change To More Sensitive Measure Of Efficacy-AVATAR Results $AVXL $ACAD