All Medicines Are Poisons (in large enough doses)! I hope that things would be so simple as just calculating IC50 and blood concentration and then passing a judgement on the therapeutic effect of the drug. Things happen in time, there is the liver, Brain Blood Barrier, intestines, stomach juices all contributing to the level of … Continue reading Mr. Brodkin And Four Arithmetic Operation But No Calculus. All About $AVXL. Part Two.
There will be number of posts on this lengthy twitter post by Jesse Brodkin, who claims to be a scientist and enterpreneur. let's see the first assertion made by Mr. Brodkin. Mr. Brodkin claimes that Anavex2-73 is being dosed 30 to 100 fold too low to engage SIGMAR1 or M-1 receptors. So let's run the … Continue reading Mr. Brodkin And His Post On Twitter About $AVXL. Part One.
This blogpost is for purposes of education only. Disclaimer. I am an owner of a modest 1,700 square feet house. My annual electric bill for about 5,200 kWh. Why did I decided to purchase a solar panel system for my house considering relatively small electricity usage? It is a rather longer story than it seems. … Continue reading Solar Panels Or Locking In The Cost Of Electricity. Energy Arbitrage In Time.
Another Paper Supports Anavex's SIGMAR1 Platform Just a day before Anavex published release with reference to a paper looking into Alzheimer's patients brain geograghy of mitochodrial dysfunction, synaptic density, oxidative stress and their impact on brain volume. All this was done in vivo that is on living AD patients as novel radiograghic markers to measure … Continue reading SIGMAR1 As Cell Stress Indicator In Alzheimer’s Points To Great Results In Phase 2b/3 For Blarcamesine. $AVXL
The Addage That Prevention Is Better Than Cure In Alzheimer's and Dementia The searche for the "cure" has been disapointing. The protocols for recruitment in clinical tests for most of the players in the game have gone from including Moderate Dementia patients to only going after those having scores on above 20 MMSE or Mild … Continue reading The Real McCoy In Pursuit of Alzheimer’s Cure Is Prevention Of Deterioration, Not A “Cure”. Anavex Sciences Narrative Goes This Way. Blarcamesine $AVXL
Going Back To The Baseline These are my first impressions from looking into the simufilam data released few days ago from the 12 months open label trial. The initial data for the 6 and 9 months included only 50 subjects. The current data includes 100 subjects. When the 9 months data was released a following … Continue reading First Impressions From Simufilam Data on Open Label 12 Month Trial. $SAVA Simufilam Blarcamesine $AVXL
The Nature Of Balrcamesine Mechanism Of Action. The detractors of $AVXL always was list the closely unknown MOA. Most drugs are working in one point in some specific pathway. Their mechanism of action can be easly indentified by a single molecule they substitute for or interact with. The MOA for Blarcamesine is so vague and … Continue reading Is Authism To Be Affected by Blacamesine? It Seems Like It. $AVXL
Is Anavex Corroborating Efficacy of Balcamesine in Azheimer's Trials Or Is It Taking From The Big Pharma Playbook The "Biomarker Cure"? On the webpage of Alzheimer's Association International Conference held in San Diego, USA July 31-August 2 2022 folowing information about poster by Anavex can be found. The title of the poster is; Study of … Continue reading Blarcamesine: “Biomarker Cure” or Strong Efficacy AAIC San Diego 2022 $AVXL Anavex2-73
Source Article link: https://medicalxpress.com/news/2022-02-team-cells-tools-huntington-als.html So.... When neuron become strassed, like in inflammation or infection, they produce proteins in respnse. In order to produce protein they need to read the right part of their DNA, and then transcribe that into messengerRNA. Then mRNA is used to create chain of amino-acids (translation) which then is folded into … Continue reading The Mystery of Familial and Sporadic Neurodegenerative Diseases Expalined. Is A Cure Found, Soon? $AVXL Blarcamesine
More Research Papers Pointing to SIGMAR1 Agonists As Possible Drugs For Alzheimer's and Parkinson's Please, read this article on the cell stress and its effect of misfolded protein in cells. Link: https://medicalxpress.com/news/2022-05-stressed-cells-clues-build-up-toxic.html In some sense this article could not be possible without the imaging technology which allows to visualize the transition from misfolded proteins to … Continue reading That Little Cell Stress That Does It….Or Right Chaperone Protein For Right Misfolded Protein In Alzheimer’s and Parkinson’s. $AVXL Blarcamesine.