Here I will refer to slide 23 of 28 on Corporate Presentation from 2-11-2019. It gives for those on Donepezil or Memantine, both drugs increase quantity of neurotransmitters involved in memory at synapses, the Average Delta (increase) Reaction Time (milliseconds) by CogState IDN (Identification) to be -25 milliseconds after 12 weeks from baseline. The same for Anavex 2-73 patients is -65 milliseconds after 5 weeks and -88 milliseconds after 17 weeks from baseline.
I add the picture of the slide later.
The first question is this new data or old data? The answer is given on to the right of the graph. It is Cogstate data collected on patients enrolled in Phase 2a and seems to cover all 32 patients or almost all as the averages on MMSE scores suggest.
The delta by itself might be misconstrued unless the absolute values are given. I do not have time to read through the papers I am going to give the link to but will just list some metrics to bring some sense of scale to those measurements.
Three Month Stability of CogState…..
The difference between those who have AD and HA (Healthy) is negligible over the 3 months measurement period (average) and may be due to learning. As it is expressed in log10, so we need to raise 10 to power x, the number given in the table, to get milliseconds of reaction time. The initial measurement is significantly different. AD (Alzheimer) 707 milliseconds and HA (Healthy) 537 milliseconds. Yet averaged over 3 months periods it is 588 milliseconds for both groups. Even at its largest magnitude, it is just 170 milliseconds of additional time (24% of 707 milliseconds) vs. HA. The improvement due to SOC is about 3.5% to 4.6% (per slide 23). Now, drum roll, the same for Anavex 2-73 is 12.4% to 16.4%.
The AD patients of the reference had avg. MMSE scores 22.16 and HA MMSE scores were 29.06. Yet the great difference was in the accuracy of recognition, not reaction time. This seemingly disappointing remark has to be upended as A2-73 appears to be lowering something which is so innate to the working of cognition that even if accuracy diminishes the timing stays roughly the same. Very interesting…
An iHub personality, XenaLives, remarked that the 5 weeks seems to be connected to the cycle of mitochondrial life span. It is another interesting thread.
Some more interesting data is on slides 11 & 12. I will look at it later.
