What I called the Unified Alzheimer's Theory calls for the root cause of Alzheimer's to be some hypothetical disturbance in cellular homeostasis, cascading into disfunction leading ultimately to wholesome destruction of neurons through/or with runaway autoimmune reaction. I have been talking about the possibility that the SIGMAR1 receptors agonists, in varing degrees, bring back the … Continue reading Athira Pharma, Synergy or Competition to Anavex? $ATHA $AVXL Blarcamesine ATH-1017
This is one is going to be personal. I have missed the webinar but I have read some impressions and quotes from the webinar on iHub. What struck me was the use of the word "happier" or "happy' in description of Rett Syndrom patients response to Blarcamesine. This ties with my own life experience. At … Continue reading Landenburg Thalmann Symposium.
Please, watch this video. It is presentation by Dr, Kaufmann (Chief Scientific Officer $AVXL) on the Pharmacokinetics OPL cohort of first Rett study. https://youtu.be/4IgtFhrVwIY I would like to highlight following points/info. "n=6 18-36 years old with MECP2 mutation". What was the most important, was that the subjects were all MECP2 mutated. Rett Syndrome is just … Continue reading Rett Syndrome Continued. Blarcamesine $AVXL
Not So Subtle Changes in RSBQ RSBQ stands for Rett Syndrome Behavioral Questionnaire. It consists of 45 questions, each questions have 3 answers, valued 0, 1 and 2. The highest possible score is 90 and represents the strongest extend of disease symptoms. Value 0 on a question corresponds to "never", 1 to "sometimes" and 2 … Continue reading Rett Syndrome Data Already Out – Anybody Pays Attention?
Dr. Missling reveals internals of the phase 2a The number of patients remaining in the phase 2a for Alzheimer's trial versus normalized to 32 patients patients remaining in placebo study (link below) Link to paper https://jamanetwork.com/journals/jamaneurology/fullarticle/775209 By the end of the first year the number of subjects dwindled from original 32 (would these 7 be … Continue reading After Conference of 3rd of December 2020….On Alzheimer’s.
Nah...Just Another Patent Claim from $AVXL. The recent patent claimes by $AVXL for ANVEX2-73 came without much cheerful response from "the community", however Dr. Missling quietly positioned Anavex to sweep almost all the chips from the table of major CNS diseases. This lack of enthusiasm can be explained that in patent application one can justify … Continue reading Glutamate, Rett Syndrome, Autism and Patent Claimes as of Recent. $AVXL Blarcamesine ANVEX2-73