Cassava Science Results vs. Anavex Life Sciences Projections $SAVA $AVXL

Baseline in $SAVA data and the same in $AVXL Phase 2a data. Picture first. There seems to be a discrepancy from calculated ADAS-Cog/MMSE baseline numbers. By ADAS-Cog11 numbers the patients in $SAVA's trial are a bit better off than the data on MMSE tests would suggests. It is difficult to interpret the data as these … Continue reading Cassava Science Results vs. Anavex Life Sciences Projections $SAVA $AVXL

ANNOVIS BIO, Mirror Mirror on the Wall…. $ANVS $AVXL $SAVA

How good are results from 25 days exploratory trial in Alzheimer's and Parkinson's? For those accustomed to measure of dementia in MMSE (Mini Mental State Examination) it comes as a shock that the actual Posiphen score are lower than placebo in MMSE. This is due to two unrelated facts. FACT 1: MMSE is notoriously insensitive … Continue reading ANNOVIS BIO, Mirror Mirror on the Wall…. $ANVS $AVXL $SAVA

How to Digest Alzheimer’s Data from AAIC 2021 $AVXL $ANVS $CRTX $SAVA

Stock Markets Reaction Is ........ There are two very basic reactions from stock market participants. A kee-jerk one where everybody buys in the rush of enthusiasm and damned be the price. "I just want to get hold of it at any price". And the measured one where the price and acquisition are weighted against each … Continue reading How to Digest Alzheimer’s Data from AAIC 2021 $AVXL $ANVS $CRTX $SAVA

AAIC 2021 as Viewed Through My Prism of Expectations $SAVA $CRTX $ATHA $AVXL

Monday 10:00 AM Eastern Time $SAVA Poster: “SavaDx, a Novel Plasma Biomarker to Detect Alzheimer’s Disease, Confirms Mechanism of Action of Simufilam” Sounds like more of "curing Alzheimer's with biomarker" or the best left for Thursday? Is there a change in narrative towards proteopathy? Proteopathy - Sickness of the protein making machinery. A bow in … Continue reading AAIC 2021 as Viewed Through My Prism of Expectations $SAVA $CRTX $ATHA $AVXL

Why Blarcamesine Might Be Working Against P. gingivalis $CRTX $AVXL $ANVS $SAVA

I have been directed by the author to an article about $CRTX and the evidence that Alzheimer's might be caused by virulence of the bacterium P. gingivalis. The bacterium can hitch a ride from the mouth on cells of the immune systen and enter the brain through the Brain Blood Barrier. Then it slowely makes … Continue reading Why Blarcamesine Might Be Working Against P. gingivalis $CRTX $AVXL $ANVS $SAVA

Alzheimer’s, Due to Fatal Infection? Cortexyme vs. Annovis Bio $CRTX $ANVS

The question is a simple one. Is Alzheimer's a disease or a syndrome?. If it is a disease then it shall have one particular etiology with one drug to it. Of course, this is a great exaggeration but serves its purpose of illustration the difference between a disease and a syndrome, which is a set of symptoms that can have varied etiology. Talking more in terms of game theory, investing in Alzheimer's drugs can be zero sum game or game where many are going to be winners, although fractionally

AAIC 2021 July 26-30 $SAVA $ANVS $AVXL

Etiology Wars The Aduhelm fiasco brings about the realization that it certainly isn't a A-beta the reason for the dementia of Azheimer's. The press still touts its sister the tau tangles. This narrative now goes through trasformation into the story of neuroinflammation with which are bound the two above-listed companies $SAVA and $ANVS. The transformation … Continue reading AAIC 2021 July 26-30 $SAVA $ANVS $AVXL

Parkinson’s Drug Delivered, Not Just Parkinson’s Disease Dementia Drug! $AVXL

Etiology Battle Won The first paragraph says it all. ANAVEX®2-73 treatment resulted in significant increase in the expression of the SIGMAR1 mRNA biomarker that significantly correlated with improvements in the primary and secondary clinical efficacy endpoints CoA (p = 0.029) and MDS-UPDRS Part III (p = 0.024) and MDS-UPDRS Total (p = 0.038) Wherever Blarcamesine … Continue reading Parkinson’s Drug Delivered, Not Just Parkinson’s Disease Dementia Drug! $AVXL

Intense Politics of Biogen’s Aduhelm and Companies like Anavex Life Sciences and Annovis. $BIIB $AVXL $ANVS

"Phase 4" and Aduhelm Biogen's Aduhelm has been approved along the line of pratice in cancer drugs field where barely promissing drugs are allowe to go on with the caveat of phase 4 - post approval verification that the efficay is there when patient numbers are large enough. No wonder that Big Pharma loves this … Continue reading Intense Politics of Biogen’s Aduhelm and Companies like Anavex Life Sciences and Annovis. $BIIB $AVXL $ANVS